A 68-year-old man presents to his GP with a 3-month history of urinary hesitancy, a weak stream, and nocturia. He has no visible haematuria or weight loss. He has no significant past medical history and takes no regular medications. A digital rectal examination reveals a firm, irregular prostate. His PSA is reported as 22 ng/mL (normal <4 ng/mL). The GP would like to refer the patient to urology due to suspected prostate cancer.